Course book Advanced Treatment Planning 2018
DOSE CONSTRAINTS FOR SBRT OF CENTRAL LC
➢ Maximum tolerated doses and optimum fractionation for mediastinal structures is currently unknown
➢ Toxicity for SBRT delivered to central tumors is not well documented
➢ Serious doubts in the validity of available data, mostly coming from retrospective series with small sample sizes
➢ Lacking, incomplete or inconsistent reporting on dose specification
➢ Questionable use of EqD2, α/ß-ratios, LQM estimates
Summary of current experiences in dose/ fraction - toxicity coherences after SBRT to the mediastinal structures that lead to LungTech normal tissue constraints
German Cancer Consortium (DKTK)
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