Course book Advanced Treatment Planning 2018
Conclusions
▪ Physical optimisation using quadratic cost functions to penalize the dose deviations seems practical, but may be too optimistic in meeting the clinical objective
▪ Radiobiological optimisation will become more trustworthy by judicious use of more accurate dose-response models
▪ Physico-biological optimisation can generate plans that are clinically recognized and fulfill the dose and dose-volume constraints based on clinical practice, while outperforming physically optimised plans
Special acknowledgements to Aswin Hoffmann who kindly provided many slides
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