Dose 2016

Including uncertainties

• Current practice not include patient specific uncertainty analysis (Setup, intra/inter fraction motion, structure delineation • Probabilistic TP (PTP) does away with PTV • Dose to an element of tissue considered as a random variable – Organs and tumour moving through dose cloud • Need to define probability density function of anticipated uncertainties – Define dose coverage to CTV not PTV – Use the multiple image data sets acquired during treatment initial fractions

Utrecht 2016