Dose 2016

How to set the Clinical tolerance limit ( TL ∆ )?

• Clinical tolerance limits or specifications should be based on clinical experience. • Clinical experience can be summarized through statistical analysis of the outcome of a particular treatment for a particular tumor disease.

Examples:

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• Local tumor control as a function of dose.

• Fraction of survivors after five years as a function of dose.

• At the same time, normal tissue complications must be taken into account.

From Jörgen Olofsson (Dose Modeling and dose verification ESTRO COURSE)