Dose 2016

Action limits - Proposed philosophy

Adjust the true dose probability distribution such that the dose limits IDC-C α /2 and IDC+C α /2 coincide with the clinical tolerance limits.

Step 3:

Prescribed dose

Probability distribution for the true dose

Dose (Gy)

is set to a minimum acceptable cure rate

TL

is set to a maximum acceptable complication rate

TL

−∆

+∆

Clinical tolerance limits

From Jörgen Olofsson (Dose Modeling and dose verification ESTRO COURSE)