Dose 2016

Probabilistic dose modeling the need for speed

Planning paradigm

Number of recalculations

CRT forward

1

PTV based IMRT

100

Probabilistic planning

100000

Most publications on probabilistic planning demonstrates proof-of-principle utilize (over)-simplified dose calculation: - translation of a single distribution neglecting attenuation variations - convolving lateral uncertainty distributions with output fluence - applicable only for a large number (>40) of dose fractions

Fast dose algorithms and smart sampling strategies needed!