Dose Course 2018_Flipping book

calculation techniques:

A singular value decomposition (SVD) trick based on the same profile invariance properties as the interpolation scheme:

Med Phys 20(2) 1993, p311-318

This is the PK implementation (for intermediate results during optimization) in RayStation Also used in Plato, and experimental systems (e.g. Voxelplan, Heidelberg)