Dose Course 2018_Flipping book

Action limits - Proposed philosophy

Step 3:

Adjust the true dose probability distribution such that the dose limits IDC-C a /2 and IDC+C a /2 coincide with the clinical tolerance limits.

Prescribed dose

Probability distribution for the true dose

Dose (Gy)

TL

is set to a minimum acceptable cure rate

TL

is set to a maximum acceptable complication rate

−D

+D

Clinical tolerance limits