EBRO 2017

Gastric cancer – adjuvant therapy

Radiation therapy alone

EBRO 2017

• Limited data • No impact on survival, reduced local recurrence

Chemotherapy alone

• Historically over 30 (mostly small) randomised trials • Meta-analyses suggest small benefit (HR 0.8) • Recent positive studies: • ACTS-GC trial (oral TS-1) Sasako M et al (2011) J Clin Oncol 29:4387-4393 • CLASSIC trial (capecitabine+oxaliplatin) Bang YJ et al (2012) Lancet 379:315-321

Concurrent chemo-radiation therapy

• No benefit in small randomized trials in 1970-80s • Gastric Surgical Adjuvant Trial INT 0116 (Macdonald et al 2001)