EBRO 2017

Elective nodal (ENI) versus involved-field irradiation (IFI)

Elective nodal (60-64 Gy)

Involved field (68-74 Gy)

p

N = 200

Local control @ 5yrs node-only failure IF failure Number To IFI 8 avoid 1 pneumonitis 9 to avoid 1 local failure @ 5 years 36 % 4 % 55 % 51 % 7 % 38 % 29% 17% .04 .03 .35 .02

Pneumonitis OS @ 2 yrs @ 5 yrs

26 % 18 %

39 % 25 %

.2

 Inoperable stage III, no PET ,  ≤ 6 cm, SC -, pleura –

 IK ≥ 80, weight loss < 10 %

 4 – 6 cycles DDP-based CT concomitantly

Yuan AJCO 2007