EBRO 2017

PET/CT guided intensity-modulated radiotherapy “dose painting” – potential limitations

• Chronically hypoxic cells have limited life-span.

• Significant changes in oxygenation status after start of

radiotherapy.

• Spatial resolution of PET-scanning and other imaging

modalities good enough for dose painting?

• Significant dose escalation (>> 80 Gy) required for large

hypoxic subvolumes. May not be feasible.