EBRO 2017
The GRADE approach
GRADE
• GR ading of recommendations, A ssessment, D evelopment and E valuations Working Group • Systematic and explicit approach to preparing evidence- based systematic reviews and clinical guidelines
GRADE categorises the quality of the evidence
• Study limitations
Large magnitude of effect
• Inconsistency of results • Indirectness of evidence
Plausible biases would reduce effect
Dose-response gradient
• Imprecision • Publication bias
Guyatt British Medical Journal 2008
ESTRO: Evidence-based Radiation Oncology
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