EBRO 2017

ARCON for T2-4 squamous cell carcinoma of the larynx

Randomization 345 pts

171

174

Accelerated Radiotherapy + carbogen and nicotinamide

Accelerated Radiotherapy

Fractionation schedule:

primary

metastatic nodes

Acc. RT

68 Gy

68 Gy

ARCON

64 Gy*

68 Gy

*Aim: improve tumor control with equal toxicity between arms!

Janssens et al. JCO 2012