EBRO 2017

BRCA gene products are involved in:

Double-strand break repair

mechanisms

Cell-cycle checkpoints control

Regulation of apoptosis

"Caretakers" genes

Involved in the maintenance of

genome integrity and stability

Protein partners of BRCA1 in DNA damage responses. There is accumulating evidence that BRCA1 performs multiple functions in the cellular response to DNA damage through its interactions with different protein partners. The list of BRCA1-interacting proteins indicated here is not exhaustive but illustrates points made in the text ( Image Permit Pending Venkitaraman,2001 ).