EBRO 2017

NCCTG 79-47-51 (1980-1986)

• 204 patients

RT Chemo-RT p value

5-year LR

63% 41% 0.0016

5-year OS

40% 55% 0.025

Late toxicity

6

7

• Reduction in death highly significant for LAR (52%, p = 0.0037) but not significant for APR (10%, p = 0.92)

Krook JE et al. N Engl J Med. 1991;324(11):709-15