EBRO 2017

Significant multivariate hazard ratios for local-component of first failure

Sample /Characteristic

Hazard ratio (95% CI)

p-value

Total sample (N = 655)

Treatment decision: BCT

4.5 (2.3 – 8.9)

<0.0001

Mastectomy

1.0

BCT sample (N = 302) Gene mutation BRCA 1

1.00

BRCA 2

2.9 (1.2 – 7.1)

0.019

Adjuvant chemotherapy Yes

1.0

No

5.4 (2.3 – 13.3)

0.0001

Mastectomy sample (N = 353) Histology

Infiltrating ductal carcinoma (IDC) IDC + lobular/Lobular carcinoma

1.0

9.9 (2.1 – 47.1) 2.7 (0.4 – 17.3)

0.0003

Medullary/Other

0.289

Pierce et al. BCRT, 2010