EBRO 2017

Clinical and pathological downstaging

• 83 patients. Resectable stage II and III .

• Randomisation

– SCRT 25/5 + delayed surgery – LCRT 46 Gy + 5-FU + delayed surgery + 4# chemo

SCRT LCRT

p value

Sphincter preservation

70.3%

69.6% 0.342

Post-op complications

40.5% 26.1% 0.221

R0 resection 86.5% 91.3% 0.734 Pathological downstaging 21.6% 39.1% 0.07

Latkauskas T. Colorectal Dis. 2012;14(3):294-8