EBRO 2017

Introduction 2

• Evidence-base is small enough • Balancing unequal considerations

• Early RT in LGG: Seizures: • PFS; OS; Cognition; Fatigue

• Good example of both strengths and weaknesses of EBM • Meta-analysis showed benefit of chemo in HGG pre-Stupp – not used • Much decision-making is non-evidence based • Trials are partial, and address only some of the questions • Sometimes with long lead times and ignoring other evidence • E.g. RTOG 98-02