EBRO 2017

Some examples

• In patients with GBM: • Chemo-RT leads to a longer survival than RT alone (Stupp, 2005) • Chemo-RT is more toxic than RT, esp. haematological toxicity (Stupp, 2005) • MGMT-methylation is associated with improved survival (Hegi, 2005)

• In patients with GBM • CRT > OS RT • CRT < Grade3-4 RT

• GBM and CRT; MGMT-meth > OS

MGMT-unmeth