EBRO 2017

Case 1

• Benefits of surgery: • No randomised data on the benefit of surgery in newly diagnosed GBM in most patients * • Repeated data from retrospective analysis of trial patients • Trials of surgical adjuvants (IO-MRI, 5-ALA) • Often group patients by extent of resection (GTR; STR; Bx) • Consistent message: • GTR > OS STR/Bx; GTR > 6mPFS STR/Bx • Less clear (but perhaps true): • GTR > OS STR > OS Bx; GTR > 6mPFS STR > 6mPFS Bx

• However, these are all post-hoc analyses • What is the obvious confounding factor here ?

* Vuorinen et al. Acta Neuro. 2003