EBRO 2017

Tra Which evidences for dose escalation?

Study (year) Populati on

Standard RT High Dose RT

Results

Beckendolf (2011)

LR – IR – HR LR – IR – HR LR – IR - HR

70 Gy

80 Gy

Better BFS

Peeters (2006) Kuban (2008)

68 Gy

78 Gy

Better BFS in IR and HR

70 Gy

78 Gy

Better BFS

Zietman (2008)

LR – IR 70.2 Gy

79.2 Gy

Better BFS in LR, strong trend in IR

Pollack (2002)

LR – IR - HR

70 Gy

78 Gy

Better BFS in IR and HR