EBRO 2017

Tra Is the adoption of BRT as boost evidence – based? Data from RCTs

Author (year)

Years of enrollement

PTS BRT schedule

EBRT dose Risk group

FUP (years)

5-y bRFS (%)

Santhia (2005)

1992-1997 51 53

- 35 Gy (HDR)

66 40

IR HR

8.2

49 71

p = 0.04

Hoskin (2012)

1997-2005 108 110

- 17 X 2 (HDR)

55 (2.75) 35.75 (2.75)

LR IR HR

12

61 75

p = 0.002

NS

RTOG 0232

2003 - 2012 296 292

LDR EBRT + LDR

125-145 45 + 125/145

IR 5

The adoption of BRT as boost could be considered evidence based