ESTRO 2020 Abstract Book

S283 ESTRO 2020

and Therapeutic Radiography. A Training Template. College of Radiographers

patients, consisting in a magnetic resonance images (MRI) database from 20 patients undergoing brachytherapy (BT) for cervix cancer and having an MRI before each brachytherapy fraction, and to develop methods for the longitudinal analysis of those data. This unique aspect of the Italian patient cohort allows investigation of RFs extracted from three anatomical regions with different characteristics: (a) muscles (i.e. tissue exhibiting non- uniformity in structure and not receiving dose, so acting as a good check for test-retest of RFs); (b) bladder filling (i.e. region exhibiting uniformity in structure and not receiving dose, so acting as a good check for test-retest of RFs) and (c) cervix tumor (i.e. tissue exhibiting non-uniformity in structure and receiving dose, so acting as a good check for effect of dose on RFs). All images (77 scans) were acquired with two different scanners but with the same protocol, and this allows evaluation of inter-scanner variability of RFs. During the two-week visit I had the possibility to discuss with experts about some possible pitfalls in radiomics workflow and RFs analysis and to use new open- source software for imaging processing, segmentation and registration. Moreover, I have improved my understanding and broaden the knowledge on harmonization strategies and dimensionality reduction methods. The preliminary results achieved on the small available population (BT Italian cohort) led to promising results and opens the possibility to a first a joint methodological publication. Moreover, future studies with bigger datasets might be considered. Throughout this visit we strengthen the cooperation between professionals involved with radiomics studies and consolidate the complementary collaboration between universities and research hospitals. The mobility grant experience was the possibility for a cultural/technical exchange between two clinical and research environments with both complementary experience and common points. SP-0517 Increasing the therapeutic index of radiation by combination with rucaparib in cervical cancer S. Saha 1 , R. Howarth 1 , A. Dubrovska 2 , K. Marchbank 3 , N. Curtin 1 1 newcastle University, Newcastle University Centre For Cancer, Newcastle Upon Tyne, United Kingdom ; 2 oncoray - National Center For Radiation Research In Oncology, Biomarkers For Individualized Radiotherapy, Dresden, Germany ; 3 Newcastle University, Complement Therapeutics Research Group And National Renal Complement Therapeutics Centre, Newcastle Upon Tyne, United Kingdom Abstract text Cervical cancer is the 4th most common cancer in women worldwide. Despite vaccination, developing countries in the Sub-Saharan Africa and South-Eastern Asia are mostly affected. In the UK, the peak age of incidence is 25-30 years with a 10-year survival rate 63%. For the locally advanced disease common treatment regimen is cisplatin ± radiotherapy. However, cisplatin induced kidney toxicity results in discontinuation of the treatment and therapy failure. The stage IVA disease is inoperable due to large tumour volume and candidates for curative radiotherapy only. Further, within these giant tumours poor availability of oxygen in blood flow results hypoxia induced radio- resistance. New therapeutic strategy is therefore urgently needed. Previous studies have shown that the PARP inhibitors (PARPi): Rucaparib TM , Olaparib TM , nicotinamide and benzamides may increase tumour blood-flow and improve tumour oxygenation. Cisplatin-induced kidney toxicity is thought to be PARP-mediated with PARPi may

SP-0515 Individualised treatment with Percussion Assisted RadioTherapy , a tool to stop respiratory motion. F. Duclos 1 1 centre Hospitalier Universitaire Vaudois, Radiooncology, Lausanne Vaud, Switzerland Abstract text Percussion Assisted RadioTherapy (PART) was first implemented in our department in 2015. It consists in assisting the patient with a percussive ventilation device to inflate lungs so that thoracic motion is stopped long enough to deliver complex RT treatments. The main advantage of this innovative technique is the reduction in toxicity to the heart and lungs with a smaller irradiated volume. Indications are limited by the capability of the patient to bear this device. Patients have to be informed, tested and trained. All the aspects of PART implementation steps will be described from the RTT point of view, particularly material, procedure, multidisciplinary team training and dosimetric results. SP-0516 Describing and characterizing the effect of brachytherapy in cervical cancer patients from radiomic feature dynamics C. Tenconi 1,2 , P. Fontaine 3 1 fondazione Irccs Istituto Nazionale Dei Tumori, Radiation Oncology 1, Milan, Italy ; 2 university Of Milan, Department Of Oncology And Haemato-Oncology, Milan, Italy ; 3 univ Rennes - Clcc Eugne Marquis-, Inserm- Ltsi – Umr 1099- F-35000, Rennes, France Abstract text Quantitative radiomic features (RFs) extracted from multimodal medical images are increasingly combined with clinical and genetic parameters to develop diagnosis or prognosis models that may serve as tools for personalized treatment and clinical decision support systems. To enhance intelligibility and applicability of radiomics studies to the clinical routine, our team is interested in studying methods for the selection of the most informative RFs in order to achieve a deeper understanding of the meaning of the individual radiomic parameters and the interpretation of the underlying biological/physical process. A fortuitous and fruitful dialogue at the last ESTRO Annual Congress gave the opportunity to set up a collaboration on this topic with French colleagues from the LTSI in Rennes who, besides having assessed unsupervised and supervised clustering methods for RFs selection, also developed a dedicated framework for image pre-processing (i.e.: resampling, normalization…) and feature extraction. Thanks to the ESTRO Mobility Grant I had the opportunity to spend two weeks in Rennes at LTSI for an exchange of knowledge and methods with the French colleagues. The general aims of the visit were: to deepen knowledge on this topic, learning and applying optimal pre-processing steps to different MRI images (T2 weighted, Diffusion-weighted imaging and apparent diffusion coefficient maps) and training on extraction and management of RFs. Moreover, the ultimate goal was to customize the radiomic pipeline developed by the French team for the Italian cohort of Symposium: Mobility grants report back