ESTRO 2020 Abstract Book

S483 ESTRO 2020

PO-0903 Cellular phones radiofrequency exposure and malignant brain tumor:sistematic review and metaanalisys A. Guaineri 1 , G. Peretto 1 , L. Triggiani 1 , A. Alghisi 1 , D. Tomasini 1 , P. Borghetti 1 , M. Maddalo 1 , S. Pedretti 1 , C. Tomasi 2 , L. Spiazzi 3 , S.M. Magrini 1 , M. Buglione 1 1 Spedali Civili di Brescia, Radiotherapy, Brescia, Italy ; 2 University of Brescia, Radiological Sciences and Public Health, Brescia, Italy ; 3 Spedali Civili di Brescia, Medical Physics, Brescia, Italy Purpose or Objective BACKGROUND In recent years there has been an increase in the incidence of new glial neoplasias diagnoses, as well as an increase in the use of mobile telephony devices has been recorded. OBJECTIVE our goal is to evaluate the role that exposure to radio frequencies emitted by mobile phones has in the onset of glial neoplasms. Material and Methods DATA SOURCES We conducted a systematic review and meta-analysis (PRISMA Statement) of articles in English, Italian, French and Spanish using EMBASE and PUBMED as search engines. The search was conducted by entering the following string:"cellular phone" OR "mobile phone" OR "wireless" ) AND ( "neoplasms" OR "cancer" OR "brain tumor" OR "glioma" OR "meningioma" OR "neurinoma". No date or publication restrictions were imposed. The last search date is April 2018. ELIGIBILITY CRITERIA / STUDY SELECTION / STUDIO DESIGN: 1595 articles were initially selected from PUBMED and 2464 from EMBASE for a total of 3035 articles eliminating the double ones. The articles were selected by 3 independent authors based on the title; subsequently selected by an author using the abstract’s information and then on the content of the text. At the end of the research we identified 17 publications concerning 14 retrospective studies.

the Random model was applied and it was significant for all the publications analyzed. DATA EXTRACTION: The combined data showed that there was an association between mobile phone use and glioma odds ratio (OR) = 1.104 (95% confidence interval [CI]: 1.031-1.177,P > 0.001). In the Funnel graphical representation relating to the so- called publication bias, such a bias is evident that we conduct a subsequent pooled analysis. The pooled analisys showed no association between the time spent in the use of the mobile phone (years of exposition) and the diagnosis of malignant brain tumors: neither for exposition less than 5 years, 5 -10 years or >10 years. The same was true if the analysis was done for patients exposed to cell phones using analogic technology compared to those exposed to mobile phones with digital technology. Analyzing the studies focusing only on the correlation between cell phones and gliomas, again it is not evident a relationship correlation between exposition and neoplasia. A further analysis demonstrates the absence of correlation between the site of glioma and the exposure to radiofrequencies (ipsilaterality or contralaterality to the use of mobile phones).

Conclusion The present analysis shows that it is not possible to demonstrate a certain correlation between the use of the mobile phone and the onset of malignant tumors of the brain. This analysis confirms what recently published by the ISTISAN 19/11 report. PO-0904 Irradiated brain volume is not related to the risk of radionecrosis: reconsidering the role of V12Gy D. Versnel 1 , S.H. Nagtegaal 1 , A. Claes 1 , E. Seravalli 1 , J.J. Verhoeff 1 1 UMC Utrecht, Radiotherapy, Utrecht, The Netherlands Purpose or Objective Cerebral radionecrosis (RN) after stereotactic radiotherapy (SRT) remains a common complication for patients with intracranial tumours. Several studies in search of prognostic factors for RN have found a relation with irradiated brain volume. Since then, SRT treatment protocols have suggested limiting the volumes receiving specific radiation doses, in particular V10Gy and V12Gy. In order to validate this finding, we have investigated whether the brain volume receiving a specific dose correlates with the risk of cerebral radionecrosis in patients with solitary brain metastases. Material and Methods In this retrospective cohort study 126 patients with solitary cerebral metastases were treated with linear accelerator based stereotactic radiosurgery at the University Medical Center Utrecht. Excluded were patients deceased before the follow-up MRI examination and patients receiving multiple cerebral radiation-based treatments. Chi-squared tests or univariable logistic regression and multivariate logistic regression were performed on variables suspect for causing RN, in order to evaluate their predictive values. There was a focus on brain volumes receiving a specific

Results STUDY EVALUATION In the overall analysis the data were extracted and measured in terms of the odds ratio (OR) and 95% confidence interval (CI) using the Fixed model. The model resulted in a heterogeneity of 88.8%, therefore