ESTRO 2020 Abstract Book

S530 ESTRO 2020

Results

Institute, Radiation Oncology, Barakaldo, Spain ; 2 Hospital Universitario Virgen del Rocio, Radiation Oncology, Sevilla, Spain ; 3 Biocruces Health Research Institute, Department of Biostatistics, Barakaldo, Spain ; 4 Cruces University Hospital/Biocruces Health Research Institute, Physics Department, Barakaldo, Spain ; 5 University of the Basque Country, Radiology, Barakaldo, Spain Purpose or Objective Several studies indicated that the proportion of patients receiving active treatment for lung cancer decreases with advancing age. There is little evidence regarding the importance of patient clinical characteristics to guide us in deciding which is the best treatment option in this population. We analysed which patterns of treatment are commonly used with curative intent in elderly patients with non-small-cell lung carcinoma (NSCLC) and predictive factors of overall survival (OS) in daily clinical practice. Material and Methods This multicentre prospective observational study included all consecutive patients aged ≥ 65 years old diagnosed with NSCLC between February 2014 and January 2017. Inclusion criteria: age ≥ 65 years, histological diagnosis of NSCLC, stages IIIA or IIIB according to the 7 th edition TNM classification, receiving radiotherapy (RT) with radical intent with a total prescribed dose of ≥ 50 Gy, with or without previous surgery, and with or without concomitant/sequential chemotherapy (CT). All treatment decisions were taken by a multidisciplinary committee in each centre. Kaplan-Meier curves and log-rank test was used to identify clinical or treatment associated variables [gender, age >or<75 years, TNM stage, KPS score, history of heart disease and diabetes, pre-treatment weight loss, baseline haemoglobin levels, smoking and drinking habits, pre- treatment quality of life (QOL] considering EORTC QLQ- C30 and LC-13 scores, treatment modality, RT technique and dose) for prediction of OS.

139 consecutive patients were recruited (Table 1). Median follow-up was 9.9 months (1.1-57.3) with a median OS of 14 months (11-17 months). In patients >75-year-old (n=112;80.6%), the multidisciplinary committee mostly recommended CT and sequential RT (n=15, 55.6%) or RT alone (n=6, 22.2%), rather than surgery (n=1, 3.7%) or concomitant RT and CT (n=5, 16.5%). In contrast, in 65- to 75-year-old patients (n=27;19,4% ), surgery and concomitant RT and CT were recommended in nearly half of cases (p=0.003). In the multivariate analysis, the risk of death was higher in patients with pre-existing heart disease p=0.002), a low score for physical functioning