ESTRO 2020 Abstract Book

S626 ESTRO 2020

At a median follow up of 75 months (range 13-109) all patient are still alive. Overall 5-year biochemical relapse- free survival (BRFS) was 92.5%, 8 biochemical relapses being observed (GG 1: 3 cases, GG 2: 2 cases, GG 3: 3 cases). Five-year local control (LC) was 94.9%, 5-year distant metastases-free survival (DMFS) was 95.1%. Cox regression analysis showed a direct correlation between WHO 2016 Grade Group and survival. In particular the hazard ratio (HR) for BRFS was 3.68 (95% C.I. 1.48- 9.12, p=0.004); HR for LC was 2.90 (95% C.I. 1.01-8.44, p=0.04); HR for DMFS was 4.52 (95% C.I. 1.29-15.79, p=0.01) Conclusion This 5-year follow-up analysis confirms that SBRT is a valid therapeutic approach for low- and intermediate risk prostate cancer patients, warranting an adequate control of disease, with mild toxicity profiles. It also confirms the significantly different prognosis, within the intermediate- risk disease, between patients with GG2 and GG3 disease. PO-1190 The 100 most cited articles in prostate cancer brachytherapy: A bibliometric study H. Zhao 1 , G. Cheng 1 , N. Wu 1 , M. He 1 , Z. Zhao 1 , N. Zhang 1 1 China-Japan Union Hospital of Jilin University, Radiation Oncology, Changchun, China Purpose or Objective Bibliometric analysis provides an objective means to describe the impact of various articles. The aim of this study was to identify the 100 most-cited research articles in prostate cancer brachytherapy (PCB) and to review characteristics of these citation classics. Material and Methods The Institute for Scientific Information (ISI) Web of Science was used to identify the 100 most cited articles in PCB as of 16 September 2019. We searched MeSH terms “Prostatic Neoplasms” and “brachytherapy” or their all Entry terms in the title, respectively, and then takes the intersection. We then reviewed the 100 most cited articles and analysis the networks visualization using VOSviewer software. Results We searched 2,489 articles to find the 100 most cited articles in PCB. The 100 most cited articles in PCB were published between 1995 and 2017, and the citations ranged from 454 to 59, which collectively had been cited 10,543 times at the time of searching. The most cited PCB article was “American Brachytherapy Society (ABS) recommendations for transperineal permanent brachytherapy of prostate cancer” at 454 citations. Besides, three recommendations from AAPM, GEC/ESTRO- EAU and GEC/ESTRO were also received high citations (150, 135 and 120; ranked 16, 22 and 26). These articles were from 11 countries, with most publications being from the United States (n=64), followed by Canada (n=8) and England (n=8), Germany (n=5), Spain (n=4) and Australia (n=3). The International Journal of Radiation Oncology, Biology, Physics produced the most articles (n=48), followed by Journal of Urology (n=11), Radiotherapy and Oncology (n=9), Cancer (n=6) and Urology (n=6). 480 co- authors contributed to the 100 most cited articles and total 2078 links between co-authors (see Figure 1). Martinez, AA has the most articles (n=10), followed by Blasko, JC (n=9), Grimm, PD (n=8), Gustafson, GS (n=6), Potters, I (n=6) and Sylvester, JE (n=6). The permanent interstitial brachytherapy (n=53) was the most widely used treatment modality, followed by the temporary brachytherapy (n=38). Quality of life (n=33) was the most topics, followed by long term outcomes (n=19). The network visualization of keywords from the 100 most cited articles according to the average published year is shown in Figure 2.

Figure 1 The network visualization of co-authors from the 100 most cited articles according to the average published year

Figure 2 The network visualization of keywords from the 100 most cited articles according to the average published year Conclusion The bibliometric analysis presents a detailed list of the 100 most cited articles in PCB. The 100 most cited PCB articles come from nineteen journals, and nearly 50% of them are