ESTRO 2021 Abstract Book

S1077

ESTRO 2021

Conclusion These early results report the feasibility of an MR-guided SBRT boost approach in patients with LA(R)GC who were not candidates for BT. When classical BT-OAR constraints are followed, acute toxicity was favorable. However, long-term follow-up is needed to validate the results. PO-1312 Quality of life in locally advanced cervical cancer: brachytherapy vs surgery after chemoradiation. M. Ferioli 1,2 , A. Galuppi 1 , M. Buwenge 1,2 , A.M. Perrone 3 , F. Deodato 4,5 , A. Re 6 , S. Cilla 7 , E. Deraco 1,8 , E. Galietta 1,2 , N. Razganiayeva 1,2 , M. Boriani 1 , S. Cammelli 1,2 , P. De Iaco 3,9 , A.G. Morganti 10,11 , G. Macchia 6 1 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2 Department of Experimental, Diagnostic and Specialty Medicine – DIMES, Alma Mater Studiorum Bologna University, Bologna, Italy; 3 Division of Oncologic Gynaecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4 Radiation Oncology Unit, Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Campobasso, Italy; 5 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy; 6 Radiation Oncology Unit, Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Campobasso, Italy; 7 Medical Physic Unit, Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Campobasso, Italy; 8 Department of Experimental, Diagnostic and Specialty Medicine – DIMES, Alma Mater Studiorum Bologna University , Bologna, Italy; 9 Oncologic Gynaecology Unit, Department Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy; 10 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 11 Department of Experimental, Diagnostic and Specialty Medicine – DIMES , Alma Mater Studiorum Bologna University, Bologna, Italy Purpose or Objective Previous studies have shown that patients with cervical cancer undergoing pelvic chemoradiation followed by brachytherapy (CRT/BT) or radical surgery (CRT/RS) have similar outcomes. However, data on any differences in Quality of Life (QoL) are lacking. Aim of this analysis is to compare long term QoL in two groups of locally advanced cervical cancer patients treated with CRT/BT or CRT/SUR. Materials and Methods Patients who underwent pelvic CRT/BT or CRT/RS in two radiotherapy departments and with a follow-up ranging from two to five years were enrolled in a questionnaire-based study. QoL and bladder, intestinal, and sexual function was evaluated with the Functional Assessment of Cancer Therapy-Cervix (FACT-Cx) including the Functional Assessment of Cancer Therapy (FACT-G), a cervix cancer-specific subscale (CxCS), and the Trial Outcome Index (TOI). Results Fifty patients (25 treated with CRT/BT and 25 with CRT/RS) were enrolled and filled out the 42-items questionnaire. Median age was 55 and 47 years in CRT/BT and CRT/RS, respectively. Most patients had stage IIB disease in both groups (76% and 72%, respectively). The only two statistically significant differences between groups were median radiotherapy (RT) dose (46 and 45 Gy, respectively) and main RT technique (3D- conformal RT and Intensity modulated RT, respectively). Significant differences in favour of CRT/RS were found in: i) CxCS scores concerning morbidity and adverse events from treatments (p = 0.004); ii) FACT-Cx TOI scores concerning physical/functional outcomes (p = 0.017); iii) FACT-Cx total score (p = 0.035). CRT/SUR scores were better, in the item- by- item comparison, in terms of: nausea, feeling bad, closeness to partner,