ESTRO 2021 Abstract Book

S1155

ESTRO 2021

(range 33 to 78). Patients reported several topics to be taken into account when making a treatment choice. These included not only outcome related issues, but also logistic and emotional issues. Cystectomy Chemoradiation Pro s * Psychological benefit of of having tumor removed from body * Psychological benefit of bladder preservation

* Surgery-related toxicity * Urinary diversion required * Prostate/uterus removed

* Radiation-related toxicity * Chemotherapy-related toxicity * Duration of treatment * Many hospital visits/ travel * Fear of radiation

Con s

* Hospital admittance

* Fear of anesthesia

Seven patients indicated that they had missed information on possible side effects or on the procedure. All patients endorsed the need for neutral and balanced information to help patients with this difficult decision. Conclusion These results indicate that the perspective of former patients has added value for developing a decision aid for MIBC patients. While the literature focusses on outcome related differences between the treatments, such as survival and toxicity, patients added emotional and logistic issues to the trade-off. A decision aid which incorporates the full patient perspective will help patients make an informed decision and choose a treatment that best matches their needs and values.

Digital Poster: Skin cancer/malignant melanoma

PO-1406 Paget's disease of scrotum and penis: Case Report of a re-irradiation and Review of the Literature A. sanfratello 1 , A. Piras 2 , L. Boldrini 3 , M. La Vecchia 1 , V. Venuti 4 , M. Torchia 1 , C. Lotà 1 , C. Rinaldi 2 , M.L. Amari 2 , M. Orlando 2 , L. Zichichi 5 , T. Angileri 6 , A. Daidone 2 1 Radioterapia Oncologica, Università degli studi, Palermo, Italy; 2 Radioterapia Oncologica, Centro San Gaetano, Bagheria (PA), Italy; 3 Radioterapia Oncologica, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Roma, Italy; 4 Radioterapia Oncologica, Uiversità degli studi, Palermo, Italy; 5 Dermatologia e Venerologia, Opedale San Antonio Abate, Trapani, Italy; 6 Radiologia, Villa Santa Teresa, Bagheria (PA), Italy Purpose or Objective Extramammary Paget’s disease (EMPD) is a rare cutaneous adenocarcinoma generally arising in the anogenital region. Surgery is still considered the treatment of choice for patients with EMPD, while Radiotherapy is a common alternative for inoperable cases and it’s necessary in case of lack of surgical radicality. In this article we described our experience and a review of the literature, with a particular focus on radiation induced toxicity and on the feasibility of re-irradiation. Materials and Methods Case Report: a 70-year-old patient with EPMD of right hemi-scrotum underwent adjuvant radiotherapy in 2015. The treatment was performed with VMAT technique for a total dose of 50 Gy in 25 fractions of 2 Gy each. After 28 months the patient showed clinical recurrence and he decided to undergo a re-irradiation approach, which was performed with an electron beam and a 10x10 cm square applicator, for a total dose of 50 Gy in 25 fractions. Both treatments were completed with good compliance and without interruptions. Review of literature: a search strategy of the bibliographic database PubMed was performed. The inclusion criteria were case report, clinical prospective or retrospective studies with histological confirmation of EMPD of scrotum and penis; studies with patients undergoing RT; studies in the past 30 years.

Results At the end of both radiant treatments no G3 (CTCAE v4) toxicity were recorded. In the last follow-up visit at 18 months of second treatment no signs of relapse were reported. At the moment, the patient maintains a good quality of life from a sexual, aesthetic and mobility point of view. The outcome of our patient was in line