ESTRO 2021 Abstract Book

S201

ESTRO 2021

showed a significant impact on DC, DFS and OS apart from classical prognostic factors as age, histological type, nodal involvement and OTT. The concordance indices (C-index with 95% CI) were 0.6735 (0.6417 – 0.7053), 0.6872 (0.6586 – 0.7158) and 0.6981 (0.6669 – 0.7292) for DC, DFS and OS respectively.

Conclusion We report new prognostic factors for disease control and survival in patients treated with IGABT for locally advanced cervical cancers.: tumor necrosis at diagnosis, distal parametrial involvement and larger CTV HR volumes at brachytherapy. These factors seem to be even more important than the FIGO Stage after chemoradiation and IGABT. OC-0296 Risk factors for severe gastrointestinal morbidity in locally advanced cervix cancer (EMBRACE study) S. Spampinato 1 , N.B. Jensen 1 , L.U. Fokdal 1 , R. Pötter 2 , C. Haie-Meder 3 , J.C. Lindegaard 1 , M.P. Schmid 2 , A. Sturdza 2 , I.M. Jürgenliemk-Schulz 4 , U. Mahantshetty 5 , B. Segedin 6 , P. Hoskin 7 , K. Bruheim 8 , B. Rai 9 , E. Wiebe 10 , R. Cooper 11 , E. van der Steen-Banasik 12 , E. Van Limbergen 13 , C. Kirisits 2 , R.A. Nout 14 , S. Chopra 5 , K. Kirchheiner 2 , K. Tanderup 1 1 Aarhus University Hospital, Department of Oncology, Aarhus, Denmark; 2 Comprehensive Cancer Center, Medical University of Vienna, Department of Radiation Oncology, Vienna, Austria; 3 Gustave-Roussy, Department of Radiotherapy, Villejuif, France; 4 University Medical Centre Utrecht, Department of Radiation Oncology, Utrecht, The Netherlands; 5 Tata Memorial Hospital, Department of Radiation Oncology, Mumbai, India; 6 Institute of Oncology Ljubljana and Faculty of medicine, University of Ljubljana, Department of Radiotherapy, Ljubljana, Slovenia; 7 Mount Vernon Hospital, Mount Vernon Cancer Centre, Northwood, United Kingdom; 8 The Radium Hospital, Oslo University Hospital, Department of Oncology, Oslo, Norway; 9 Postgraduate Institute of Medical Education and Research, Department of Radiotherapy and Oncology, Chandigarh, India; 10 Cross Cancer Institute and University of Alberta, Department of Oncology, Edmonton, Canada; 11 St James's University Hospital, Leeds Cancer Centre, Leeds, United Kingdom; 12 Radiotherapiegroep Arnhem, Department of Radiotherapy, Arnhem, The Netherlands; 13 UZ Leuven, Department of Radiation Oncology, Leuven, Belgium; 14 Leiden University Medical Center, Department of Radiation Oncology, Leiden, The Netherlands Purpose or Objective To identify risk factors for severe gastrointestinal morbidity in locally advanced cervical cancer (LACC) patients treated with external beam radiotherapy (EBRT), concomitant chemotherapy and image-guided adaptive brachytherapy (IGABT). Materials and Methods Data from the prospective, multi-institutional, observational EMBRACE I study (an international study on MRI-