ESTRO 2021 Abstract Book

S246

ESTRO 2021

Conclusion The number of elderly oncologic patients is progressively increasing and the importance of ensure older- person-centered care plans is growing day by day. This study is still ongoing. Preliminary results confirmed that G8q represents a simple tool to identify frail patients in daily practice, and that thanks to this evaluation most of elderly patients with indication to curative RT did not showed a fragile phenotype. Finally, the support of a multidisciplinary approach in vulnerable patients resulted useful in order to obtain their compliance to the treatment without increased toxicity.

Proffered papers: Highlights of Proffered Papers - Latest Clinical Trials

OC-0333 Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial A. Laprie 1 , G. Noel 2 , L. Chaltiel 3 , G. Truc 4 , M. Sunyach 5 , M. Charissoux 6 , N. Magné 7 , P. Auberdiac 8 , S. Ken 9 , F. Roux 10 , L. Vieillevigne 9 , F. Tensaouti 11 , I. Catalaa 12 , S. Boetto 10 , E. Uro-Coste 13 , S. Supiot 14 , V. Bernier 15 , T. Filleron 16 , M. Mounier 17 , M. Poublanc 17 , J. Delord 18 , E. Cohen-Jonathan-Moyal 11 1 ICR - IUCT-oncopole, Radiation Oncology, Toulouse, France; 2 ICANS, Radiation Oncology, Strasbourg, France; 3 ICR - IUCT-oncopole, Biostatistics, Toulouse, France; 4 Centre Georges-François Leclerc , Radiation Oncology, DIJON, France; 5 Centre léon Berard, Radiation Oncology, Lyon, France; 6 ICM, Radiation Oncology, Montpellier, France; 7 Institut de Cancérologie de la Loire, Radiation Oncology, Saint-Priest en Jarez , France; 8 Clinique Claude Bernard, Radiation Oncology, Albi, France; 9 ICR-IUCT-oncopole, Radiophysics, Toulouse, France; 10 CHU de Toulouse, Neurosurgery, Toulouse, France; 11 ICR-IUCT-oncopole, Radiation Oncology, Toulouse, France; 12 CHU de Toulouse, Radiology, Toulouse, France; 13 CHU-IUCT-oncopole, Pathology, Toulouse, France; 14 ICO, Radiation Oncology, Nantes, France; 15 ICL- CAV, Radiation Oncology, Vandoeuvres-les-Nancy, France; 16 ICR- IUCT-oncopole, Biostatistics, Toulouse, France; 17 ICR-IUCT-oncopole, Clinical Research Office, Toulouse, France; 18 ICR-IUCT-oncopole, Medical Oncology, Toulouse, France Purpose or Objective Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries a dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this is still low due to local relapses, mostly occurring in the irradiation field. As the ratio of spectra of choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging has been described as predictive for the site of local relapse, we hypothesized that dose escalation on these regions would increase local control and survival[1]. Materials and Methods In this multicenter prospective phase III trial for newly diagnosed glioblastoma, 180 patients having undergone biopsy or surgery were randomized to 2 arms. Arm A was the Stupp protocol (EBRT 60 Gy on contrast enhancement + 2 cm margin with concomitant temozolomide (TMZ) and six months of TMZ maintenance). Arm B was the same treatment with an additional simultaneous integrated boost of intensity-modulated radiotherapy (IMRT) of 72Gy/2.4Gy delivered on the MR spectroscopic imaging metabolic volumes of CHO/NAA>2 and contrast-enhancing lesions or resection cavity. Stratification was performed on surgical