ESTRO 2021 Abstract Book

S788

ESTRO 2021

Posters

Digital Poster: Head and neck

PO-0944 Correlation on G8 score with sarcopenia is a prognostic factor for OS in patients with HNC K. Zhelev 1 , Z. Zahariev 1 , D. Katsarov 2 , I. Mihaylova 2 , N. Conev 3 , I. Donev 4 1 MHAT Uni Hospital, Clinic of Radiotherapy, Panagyuriste, Bulgaria; 2 SHAT of Oncology, Clinic of Radiotherapy, Sofia, Bulgaria; 3 UMHAT St.Marina, Clinic of Medical Oncology, Varna, Bulgaria; 4 MHAT Nadezhda, Clinic of Medical Oncology, Sofia, Bulgaria Purpose or Objective Sarcopenia (low muscle mass) is an emerging syndrome associated with poor outcome in cancer patients. We investigated the relation between skeletal muscle index (SMI), Geriatric score 8 (G-8) and overall survival (OS) in a p16 negative group of patients with head and neck cancer (HNC). Materials and Methods A retrospective study in patients with HNC treated between 2016 and 2019 was performed. A total of 87 patients with unresectable HNC in Stages II disease, treated with cisplatin concurrent radiotherapy, wеre included in this study. The amount of skeletal muscle mass was defined using theSMIat the level of C3 sternocleidomastoid and paravertebral muscleson the first computed tomography (CT) staging scan. Sarcopenia was present when SMI fall below published non‐gender specific thresholds cut‐off point of <43.2 cm2/m2.The G-8 score is use as a screening tool to evaluated frailty. The frailty questionnaire is designed for onco‐geriatric patients, with seven points derived from the Mini Nutritional Assessment and one relative to patient age. A threshold is suggested at 14 points, meaning that a patient with a score of ≤ 14 had a poor functional status of a patient. Results The cohort included 66 men (75.9%) and 21 women (24.1%), with a total mean age of 64 (±10.2) years. Patients with performance status (PS) 0 were 7 (8%) PS 1 59 (67.8%) PS 2 21(24.1%). Sarcopenia was present in 39 (44.8%) patients, of which 20 (51.3%) men and 19 (48.7%) woman. A total of 41 (47.1%) patients with G-8 score ≤ 14 were defined as frailty. Skeletal muscle mass status, measured with SMI correlated moderately with G-8 frailty score (r = 0.37, p < 0.001). No relationship between PS and sarcopenic frailty patients was found. Patients with G-8 score > 14 were associated with decrease risk of progression on the first control CT scan (OR 0.39, 95% CI: 0.16-0.93, p=0.035). Frailty patients had a significantly shorter mean OS (17.1months; 95%, CI: 14.7-19.6) than the rest of the patients (35.6 months; 95%, CI 29.1-42.8) (log-ranktest p=0.017). Those with sarcopenia had numerically short term OS (19.6 months; 95%, CI: 17.7-21.9) than the rest of the group (29.1 months; 95%, CI: 22.1-36.1).In addition, multivariate Cox proportional hazards regression model showed, that only G-8 score ≤14 was an independent risk factor for worse OS, (HR=4.2, 95% CI: 1.8-10.7, p=0.002). Conclusion Sarcopenia correlated moderately with G-8 frailty score. Low G-8 score is an independent negative predictor of short OS and this questionnaire may be helpful evenin younger patients. PO-0945 The prognostic value of RDW, NLR, and PLR in radiotherapy for oropharyngeal cancer E. Staniewska 1 , B. Tomasik 2 , R. Tarnawski 1 , M. Miszczyk 1 1 Maria Skłodowska-Curie National Research Institute of Oncology, III Department of Radiotherapy and Chemotherapy, Gliwice, Poland; 2 Medical University of Łódź, Department of Biostatistics and Translational Medicine, Łódź, Poland Purpose or Objective To assess the impact of red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet- to-lymphocyte ratio (PLR) on the overall survival (OS) of the patients with oropharyngeal cancer. Materials and Methods This retrospective study includes 208 patients treated for oropharyngeal cancer with radiotherapy or radio- chemotherapy at one institution between 2004 and 2014. The receiver operating characteristic (ROC) method, log-rank testing, and Cox proportional hazards regression model were used for the analysis. Results The RDW index was characterized by the highest discriminatory ability (AUC=0.59), closely followed by NLR (AUC=0.58). The OS was significantly higher in RDW ≤13.8% (p=0.001) and NLR ≤2.099 (p=0.016) groups. Due to the low AUC of PLR in ROC analysis (AUC=0.51), the log-rank testing was omitted. In the univariate Cox Regression analysis, RDW (1.28, 1.12-1.47, p<0.001) and NLR (1.11, 1.06-1.18, p<0.001) were associated with increased risk of death. In the multivariate analysis, neither of the analyzed indices were significantly associated with survival. Univariate and multivariate Cox Regression analysis of HR for OS in patients with squamous cell carcinoma of the oropharynx

Covariates a

Univariate HR Univariate p-value Multivariate HR Multivariate p-value

Sex

1.83(1.18-2.82) 0.007

1.65(1.05-2.59) 0.029

Pack-years

1.01(1.00-1.02) 0.016

1.00(0.99-1.01) 0.540

ZUBROD (2>1>0)

1.47(1.09-1.96) 0.010

1.09(0.79-1.50) 0.604

Addition of chemotherapy 0.54(0.38-0.78) 0.001

0.57(0.38-0.86) 0.007