ESTRO 2022 - Abstract Book

S1241

Abstract book

ESTRO 2022

Conclusion RT20 and RT30 schedules are equally effective in the management of SCC. The lower OS of the RT20 patients strongly suggests a selection bias towards the use of this scheme in patients with a worse prognosis.

PO-1462 High radiation dose delivery by lattice-rt to hypoxic areas in bulky tumours: a multicentric study.

S. Parisi 1 , G. Ferini 2 , A. Pontoriero 1 , A. Viola 3 , A. Cacciola 1 , S. Lillo 1 , G. Ferrantelli 1 , C. Tamburella 1 , G. Lo Giudice 1 , V. Valenti 2 , A. Tripoli 2 , F. Chillari 1 , S. Pergolizzi 1 1 G. Martino Messina University Hospital, Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, Messina, Italy; 2 REM Radiotherapy srl, Radiotherapy and Clinical Oncology, Viagrande, Italy; 3 IOM Foundation, Radiotherapy and Clinical Oncology, Viagrande, Italy Purpose or Objective To evaluate feasibility, toxicities and clinical response in Stage IV patients with bulky tumour treated with LATTICE technique. The aim of the present study, called LATTICE_01, is to deliver high doses of radiation to hypoxic areas within the gross tumour volumes (GTV). The goals of this innovative approach are to stimulate abscopal effect and to activate bystander effect on the nearby normoxic areas. Materials and Methods From June 2020 to October 2021 we selected all metastatic patients with bulky tumour both unresectable and unsuitable to ablative radiotherapy in the experimental centers (G. Martino Messina University Hospital, REM Radiotherapy srl Viagrande, IOM Viagrande Foundation). Among these, we enrolled the patients who had a Karnofsky Performance Status (KPS) ≥ 60, a life expectancy major of six months and permissive clinical/biochemical parameters.