ESTRO 2022 - Abstract Book

S219

Abstract book

ESTRO 2022

equal-sized buckets and processed through logistic regressions in order to determine optimal bucket numbers and respective cut-offs in reference to the explored risk factors: OS, DFS, metastasis-free survival (MFS) and local control (LC). Results A total of 679 pts were eligible for analysis: 408 (6.1%) were males, median age was 65 years (range 23-91) [Table 1]. RT was delivered with a median dose of 55 Gy (range 19.8-58.5). In our analysis [Table 2] we found a significative association between SII, NLR and HEI with OS (p-value of 0.04, 0.01, and 0.002 respectively). We identified a cut-off value for SII and NLR (615.08 and 2.55, respectively); pts with a lower value showed a worse OS compared with those with higher baseline values. Regarding HEI index, pts were divided into 2 groups according to their score (0-1 and 2-3 respectively); pts with ≥ 2 had a worse OS. PLR and MLR failed to show significative association with OS; we also failed to observe association between all markers and DFE, MFS and LC.

Conclusion These data suggest a possible correlation between baseline inflammatory parameters and oncological outcomes, in particular OS, possibly related to host response to the tumor. A deeper insight into both systemic and local inflammatory markers could lead to the development of decision making tools.

Proffered Papers: Immuno-radiobiology

OC-0261 ATR inhibition promotes IFN signaling via G2 checkpoint abrogation in irradiated human cancer cells

A. Eek Mariampillai 1 , S. Hauge 1 , I. Øynebråten 2 , G.E. Rødland 1 , A. Corthay 2,3 , R.G. Syljuåsen 1