ESTRO 2022 - Abstract Book

S228

Abstract book

ESTRO 2022

0.04. Loco-regional control is outlined in figure 2, showing a non-significant trend for a relation between “more“ hypoxic tumors and decreased loco-regional control compared to “less” hypoxic tumors, with a hazard ratio of 4.48 (0.82 – 24.48) and risk difference of 11.6%. Conclusion Conclusion: Expression of the hypoxia related genes from the 15-gene hypoxia classifier is similar in SCC of the uterine cervix, HNSCC and SCCA, and independent of p16 status, indicating that the classifier is representative for hypoxia in SCC in general. This hypothesis generating study is the first to correlate hypoxia to outcome in SCCA and the results indicates that clinical studies investigating hypoxia modifying treatment for SCCA may be relevant.

OC-0272 External validation of the Hemo-Eosinophils-Inflammation index as a prognosticator in anal cancer

P. Franco 1 , A. Porreca 2 , M. Di Nicola 3 , G. Mantello 4 , F. Valvo 5 , N. Slim 6 , S. Manfrida 7 , M.A. Gambacorta 8 , F. De Felice 9 , S. Vagge 10 , M. Krengli 1 , E. Palazzari 11 , M.F. Osti 12 , A. Gonelli 13 , G. Catalano 14 , P. Pittoni 15 , M. Lupattelli 16 , M.R. Niespolo 17 , M.E. Rosetto 18 , G. Macchia 19 , O. Durante 20 , F. Munoz 21 , R.M. D'Angelillo 22 , D. Genovesi 23 , L. Caravatta 24 1 University of Eastern Piedmont, Department of Translational Medicine, Novara, Italy; 2 "G. D'Annunzio" University of Chieti-Pescara, , Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, Chieti, Italy; 3 "G. D'Annunzio" University of Chieti-Pescara, Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, Chieti, Italy; 4 Azienda Ospedaliero Universitaria Ospedali Riuniti, Department of Oncology and Radiotherapy, Ancona, Italy; 5 CNAO National Center for Oncological Hadrontherapy, Radiotherapy Unit, Clinical Department, Pavia, Italy; 6 IRCCS San Raffaele Scientific Institute, Department of Radiotherapy, Milano, Italy; 7 "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radiotera-pia Oncologica ed Ematologia, Rome, Italy; 8 "A. Gemelli" IRCCS, Fondazione Policlinico Universitario, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy; 9 Policlinico Umberto I, "Sapienza" University of Rome, Department of Radiotherapy, Rome, Italy; 10 IRCCS Ospedale Policlinico San Martino, Department of Radiation Oncology, Genua, Italy; 11 Oncological Referral Center, Radiation Oncology Department, Aviano, Italy; 12 Sant'Andrea Hospital, Sapienza University of Rome, Unit of Radiation Oncology, Rome, Italy; 13 Azienda Ospedaliero-Universitaria Pisana, Department of Radiotherapy, Pisa, Italy; 14 IRCCS Multimedica, Radiation Oncology Center, Sesto San Giovanni, Italy; 15 Asst Lariana, Ospedale di Como, Radiation Oncology Unit, Como, Italy; 16 University of Perugia and Perugia General Hospital, Radiation Oncology Section, Perugia, Italy; 17 Azienda Ospedaliera San Gerardo, Radiotherapy Unit, Monza, Italy; 18 Belcolle Hospital, Radiotherapy Unit, Viterbo, Italy; 19 Gemelli Molise Hospital – Università Cattolica del Sacro Cuore, Radiation Oncology Unit, Campobasso, Italy; 20 Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Radiation Oncology,