ESTRO 2022 - Abstract Book

S238

Abstract book

ESTRO 2022

Conclusion This study demonstrates that the hybrid EMT/BT system can detect treatment errors and needle reconstruction inaccuracies in HDR BT cervix patients in a clinical setting.

Proffered Papers: FLASH

OC-0279 FlashDC project: development of a beam monitor for FLASH therapy

A. Trigilio 1,2 , D. Carlotti 1,2 , A. De Gregorio 1,2 , P. De Maria 3 , M. De Simoni 1,2 , M. Fischetti 4,2 , G. Franciosini 1,2 , M. Garbini 5 , M. Marafini 2,5 , A. Muscato 1 , V. Patera 4,2 , A. Schiavi 4 , A. Sciubba 4,2 , M. Toppi 4,6 , G. Traini 2 , A. Sarti 4,2 1 Sapienza University of Rome, Department of Physics, Rome, Italy; 2 INFN National Institute for Nuclear Physics, Roma I Section, Rome, Italy; 3 Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Rome, Italy; 4 Sapienza University of Rome, Department of Basic and Applied Sciences for Engineering, Rome, Italy; 5 CREF Historical Museum of Physics and “Enrico Fermi” Study and Research Center, Researcher, Rome, Italy; 6 INFN National Institute for Nuclear Physics, National Laboratory of Frascati Section, Rome, Italy Purpose or Objective Over the past decades, research in Radiotherapy (RT) has been focused on the goal of reducing damages from additional dose to healthy tissues whilst retaining high tumor control probability. Recent preclinical studies suggest that a new approach could be adopted by exploiting beams with ultrahigh dose-rates (up to 10 7 Gy/s instantaneous dose-rate in a single pulse) to deliver the whole planned dose in a very short time (<200 ms), thus triggering what has been called FLASH effect, consisting of a tumor control probability comparable to standard RT and reduced toxicity to healthy tissues. However, the biological in vivo validation of FLASH effect is hindered by many open issues. One of the most urgent ones is