ESTRO 2022 - Abstract Book

S341

Abstract book

ESTRO 2022

Results The gQA results are summarized as boxplots in Fig. 2a. Four out of five DIRs gave acceptable Dice scores, while one (NiftyReg) performing even worse than rigid registration. This algorithm was therefore eliminated from the subsequent dosimetric analysis, shown in Fig. 2b, where substantial differences in the accumulated dose DVHs can be seen for the patient with the largest anatomical changes. Additionally, dose indexes for V95-PTV and left parotid D20 for all patients show pronounced differences, highlighting the importance of dose variations in accumulated dose due to choice of DIR. Finally, our model-based estimation of these uncertainties resulted in >90% voxel with a prediction error < 5%, which was comparable (91.6% vs. 92.4%) for both sequential and SIB plans (Fig. 2c).