ESTRO 2022 - Abstract Book

S517

Abstract book

ESTRO 2022

hospital (96%) or ED (4%). The majority of those visits were associated with male sex (n=3,766) and the median age was 62 years. The three most common MSUD diagnoses among cancer patients were alcohol related disorders, anxiety disorders, and depressive disorders. Alcohol related disorders were more common among patients with tumors of the liver, head and neck, and gastrointestinal tract . Anxiety and depressive disorders were most common among patients with thyroid cancer, Hodgkin’s Disease, breast, uterine, and ovarian cancers. Opioid related disorders were found more commonly in patients with secondary malignancies, multiple myeloma, pancreatic cancer, and cancer of the bone and connective tissue. The total costs associated with a primary MSUD between 2009-2018 was $3,018,279,540. Alcohol-related disorders, suicidal ideation or attempt, anxiety disorders, and depressive disorders made up 64% of all costs associated with a primary MSUD. Younger age (OR: 0.99, 95% CI: 0.98-0.99, p<0.001) and female sex (OR: 1.34, 95% CI: 1.32-1.35, p<0.001) were associated with higher odds of having an MSUD. Conclusion Our findings demonstrate a high burden of psychiatric and substance use illness in the cancer population and provide the rationale for early psychosocial intervention to support these patients. J.P. AGARWAL 1 , S. Sinha 2 , S. Lewis Salins 3 , S. Pandey 4 , J. Deodhar 5 , N. Salins 6 , S. Ghosh Laskar 7 , A. Budrukkar 2 , T. Gupta 2 , V. Murthy 2 , M. Swain 2 , S. Nair 8 , P. Chaturvedi 8 1 Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, Department Of Radiation Oncology, MUMBAI, India; 2 Tata Memorial Centre, Homi Bhabha National Institute, Department Of Radiation Oncology, MUMBAI, India; 3 Kasturba Medical College, Department of Radiotherapy and Oncology, Manipal, India; 4 Apollo Hospital, Department of Radiation Oncology, Lucknow, India; 5 Tata Memorial Centre, Homi Bhabha National Institute, Department of Palliative Medicine, MUMBAI, India; 6 Kasturba Medical College, Department of Palliative Medicine, Manipal, India; 7 Tata Memorial Centre, Homi Bhabha National Institute, Department Of Radiation Oncology, MUMBAI, India; 8 Tata Memorial Centre, Homi Bhabha National Institute, Department of Head and Neck Surgery, MUMBAI, India Purpose or Objective Around 30-50% of Head Neck squamous cell cancer (HNSCC)patients experience elevated levels of distress. An elevated level of distress is associated with poor health related Quality of Life (QoL), decreased patient satisfaction, poor treatment compliance and possible reduced survival. Can Specialist care may help in improving the outcomes! Materials and Methods This Randomized prospective trial from a single center in India enrolled HNSCC patients aged > 18 years who received curative Radiation Therapy (RT) and had a baseline significant distress as per the NCCN distress thermometer (distress score ≥ 4).Patients were randomized into the Standard arm (STD),which included an assessment and interview with the treating physician for distress screening and alleviation, or the Interventional arm (INV), where psycho-oncology/ palliative care referral was done at baseline and every week during treatment. Block randomization was done in a1:1 allocation ratio with stratification for treatment (definitive vs. adjuvant), age (< 65 vs. ≥ 65 years), and primary site (Oral cavity vs. non- oral cavity). The study's primary endpoint was the proportion of patients having significant distress 6 months post- treatment. The trial was powered to detect a 20% difference in significant distress between the 2 arms with 80% power and 5% significance level (2-sided), requiring 106 patients in each arm (10% attrition rate). The secondary endpoints included symptom burden assessment by the Edmonton Symptom Assessment Score (ESAS), QoL (assessed by EORTC QLQC30 & HN 35), and survival. The study was registered with the Clinical Trial Registry of India (CTRI/2016/01/006549) Results Three hundred and forty patients were screened, 212 patients were randomized (n=104 STD, n=108 INV). At 6 months post- treatment completion, 89 and 90 were evaluable in the STD and INV, respectively. The median distress score at baseline for both arms was 6 (IQR:5-8). At 6 months post-treatment completion, the median distress score was 2(IQR:2-3) in both arms. There was no significant difference in the proportion of patients having significant distress at 6 months post- treatment completion in STD vs. INV (16 vs. 9.3%, p=0.19). There was no significant difference between arms in other distress checklist domains (physical, practical, family, spiritual and social). At 6 months after treatment, there was an improvement in all symptoms measured by the ESAS (pain, tiredness, drowsiness, nausea, lack of appetite) & the QoL for the entire cohort with no statistically significant difference between arms. The 3-year Overall Survival for STD vs. INV was (70 vs 66%, p=0.56). Conclusion Psycho-oncology and palliative care referral did not impact distress, symptom burden, quality of life or survival significantly in this randomized trial. The primary treating oncologist should screen for elevated distress in patients of HNSCC and continue to provide wholesome care for their patients. OC-0592 Impact of palliative care referral on distress in patients undergoing RT for HNSCC: Randomized Trial

Proffered Papers: Microenvironment

OC-0593 SPECT Imaging of CAIX and monitoring of hypoxia after OXPHOS inhibition in murine tumor models

D. Boreel 1 , P. Span 2 , H. Peters 2 , A. Kip 3 , M. Boswinkel 3 , G. Adema 2 , S. Heskamp 3 , J. Bussink 2