ESTRO 2022 - Abstract Book

S600

Abstract book

ESTRO 2022

Significance could not be shown for DMFS. Additionally, we presented a nomogram for OS prediction according to used

scoring systems.

Conclusion The prognostic role of scoring systems in the OS results of the geriatric patients with stage III NSCLC has been demonstrated. Moreover, we determined a nomogram for predicting OS according to used systems. Our research is unique in terms of this issue. We think that the use of G8 scoring will be beneficial when determining our treatment decisions and doses, and it will be important to examine the definitive or palliative treatment decision with prospective studies in patients with an unfavorable prognosis according to nomogram, G8, GPS, and PNI.

PD-0666 The role of Agatston score in stage III non small cell lung cancer patients

A. Angrisani 1 , G. De Marco 1 , V. Nardone 1 , E. D'Ippolito 1 , R. Grassi 1 , A. Reginelli 2 , C. Guida 3 , S. Cappabianca 1

1 "L. Vanvitelli" University of Campania, Precision Medicine - Radiotherapy Unit, Naples, Italy; 2 "L. Vanvitelli" University of Campania, Precision Medicine - Radiology Unit, Naples, Italy; 3 Ospedale del Mare, Radiotherapy, Naples, Italy Purpose or Objective Radiation-induced cardiac toxicity and radiation-related coronary artery disease (CAD) represent an important issue in thoracic radiotherapy, although no reliable surrogate biomarkers are identified. The quantification of coronary calcium based on the area of a calcified coronary plaque in a CT slice is called Agatston score, or Coronary Artery Calcification Score (CAC Score) and could represent a potential biomarker for radiation-induced cardiac toxicity. The aim of our work is to evaluate the prevalence and severity of cardiac calcifications in third-stage lung cancer patients before radical chemo- radiotherapy treatment. Materials and Methods Between January 2018 and May 2021, patients with Stage III non-small cell lung cancer (NSCLC) with a pre-treatment CT imaging of the thorax that was discussed in the Multidisciplinary Tumor Board (MTB) of thoracic malignancies in our Department were included. The clinical data of the patients were retrospectively collected (sex, age, smoke exposure, stage) and the Agatston score was calculated on CT imaging and was correlated with the clinical parameters (Chi-Square analysis) and with overall survival (OS, with Kaplan-Meier analysis). Results A total of 84 patients were included in the present analysis, , with a median OS of 30 months (mean 34,2 months, 95% CI 28-40 months). The four CAD Score subgroups differed in terms of sex (p:0,010), age (p<0,001) and smoke exposure (p:0,001). The parameters that resulted significantly correlated with a lower OS were the Stage (p<0,001) and the CAD Grading (p:0,001). Conclusion The prevalence of severe CAC Grading is exceedingly high in locally advanced lung cancer patients that are amenable to undergoing different treatments. This subset of patients, independently from the choice of treatment, should be referred to the Cardiologist for prevention and strict follow-up of CAD.