ESTRO 2022 - Abstract Book

S675

Abstract book

ESTRO 2022

Conclusion Our study has a very long median follow-up of about 10 years with a homogeneous population, pathology and radiation treatment. Our analysis led to the identification of a precise threshold dose. We need prospective confirmation of our results in larger cohorts that also take into account the assessment of quality of life.

OC-0760 Active surveillance is safe for asymptomatic radiation-induced meningiomas in cancer survivors

M. Xu 1 , A. Lasocki 2 , M. Bressel 3 , N. Goroncy 4 , J. Seymour 5 , G. Wheeler 1 , M. Dwyer 1 , K. Wiltshire 1 , N. Haghighi 1 , K. Mason 5 , D. Tange 6 , B. Campbell 1 1 Peter MacCallum Cancer Centre, Department of Radiation Oncology, Melbourne, Australia; 2 Peter MacCallum Cancer Centre, Department of Cancer Imaging, Melbourne, Australia; 3 Peter MacCallum Cancer Centre, Centre for Biostatistics and Clinical Trials, Melbourne, Australia; 4 Peter MacCallum Cancer Centre, Department of Cancer Nursing, Melbourne, Australia; 5 Peter MacCallum Cancer Centre, Department of Haematology, Melbourne, Australia; 6 Peter MacCallum Cancer Centre, Department of Cancer Surgery, Melbourne, Australia Purpose or Objective Radiation-induced meningiomas (RIM) are the most common intracranial secondary neoplasm in childhood cancer survivors. Although routine MRI screening for RIM remains controversial, many patients present asymptomatically. The natural history and long-term outcomes for asymptomatic RIM are poorly understood. This retrospective study describes the radiological growth rate and clinical outcomes of asymptomatic RIM in cancer survivors previously treated with cranial or spinal radiotherapy. Materials and Methods Eligibility included long-term cancer survivors enrolled in the Peter MacCallum Late Effects Clinic with ≥ 1 RIM identified on MRI from 1/1/1990 to 1/11/2015. MRI scans were centrally reviewed. Radiological growth rate was calculated for patients managed by active surveillance with ≥ 2 serial MRI scans available for central review.

Results