ESTRO 2022 - Abstract Book

S793

Abstract book

ESTRO 2022

Purpose or Objective The detection of the electromagnetic signal, in particular the magnetic field generated by a proton beam, has been proposed as a range verification approach for ion beam therapy. In this work, we investigate the impact of secondary particles from a proton pencil beam stopping in water on the magnetic field created by the primary protons. Materials and Methods With Monte Carlo (MC) we accurately simulated low-energy interactions through the Geant4-DNA extension. We exported particle phase spaces of MC simulated proton pencil beams in water with variable spot sizes and a peak beam current of 0.2 µA, in agreement with current performance of pulsed synchrocyclotron accelerators. Subsequently, we calculated individual and average charge and current density of protons and secondary electrons for a statistical analysis, also serving as an input of a finite element analysis (FEA) that estimates the magnetic field. The FEA exploits the beam's cylindrical symmetry and has been adjusted to allow for non-solenoidal current densities, as necessary for a stopping proton beam. Results The proton charge density rises towards the range and is not perturbed by energy straggling. The losses due to nuclear reactions are up to 15% and allow an approximately constant longitudinal current density. The proton density is however relatively low (at most 0.37 protons per mm ³ for the 0.2 µA current), leading to considerable current density fluctuations. These are even stronger for the radial current, which is yet two orders of magnitude weaker than the longitudinal current and therefore largely negligible. Secondary electrons, that far outnumber the primary protons by at least a factor of 10, reduce the primary proton current by only 10% due to their mostly isotropic flow. Only a small fraction of those electrons (<1%) undergoes head-on collisions. These higher energy electrons with Q_e>1 keV have a longitudinal drift along the beam line (see Fig. 1). In the far-field, both contributions to the magnetic field strength (longitudinal and lateral) are independent of the beam spot size. We also find that nuclear reaction related losses cause a shift of 1.3 mm to the magnetic field profile relative to the actual range, which is further enlarged to 2.1 mm by the electron current. While the current density variations cause significant magnetic field uncertainty close to the central beam axis with a signal-to-noise ratio (SNR) close to one, they average out at a distance of 10 cm with the SNR of the total magnetic field rising to 45.

Conclusion We find that the primary protons constitute the dominant component of a proton pencil beam's current density, despite the significantly larger electron charge density. With the high SNR of the magnetic field, our analysis encourages its experimental detection through sensitive instrumentation, such as optical magnetometry.

PD-0900 Proton FLASH painting for improved target dose coverage and robustness near risk organs

P. Poulsen 1 , S. Nankali 1 , J. Kallehauge 1 , C. Grau 1 , M. Høyer 1 , B.S. Sørensen 2 , J. Petersen 3 , A. Vestergaard 1

1 Aarhus University Hospital, Danish Center for Particle Therapy, Aarhus, Denmark; 2 Aarhus University Hospital, Department of Experimental Clinical Oncology, Aarhus, Denmark; 3 Aarhus University Hospital, Department of Medical Physics, Aarhus, Denmark Purpose or Objective FLASH radiotherapy can reduce normal tissue damage while maintaining the tumor response. FLASH with proton beams may be obtained with high energy transmission beams at the cost of poorer dose conformality. Here, we propose FLASH painting as a method to deliver proton FLASH therapy with uncompromised dose distributions. FLASH painting only delivers FLASH dose rates in smaller volumes, where the FLASH sparing effect is mostly needed. It makes it easier to obtain FLASH dose rates. This study shows how proton FLASH painting may improve proton therapy of tumors near the brain stem. Materials and Methods Proton FLASH painting plans were made for two patients previously treated with proton therapy for a meningioma (Patient 1) and an anaplastic oligodendroglioma (Patient 2). The prescribed dose was 59.4Gy in 33 fractions. Since the clinical target