ESTRO 2022 - Abstract Book

S801

Abstract book

ESTRO 2022

Conclusion In our small cohort of patients treated for gynaecological cancer, the median bowel loop motion decreased at the end of EBRT, and this was even more pronounced at time of brachytherapy with an applicator in situ. In addition, there is a trend towards a further decelerated bowel loop motion after concurrent chemotherapy. This study strengthens the need for further research aiming to control for bowel loop motion in our future pelvic radiotherapy planning.

PD-0906 Functional MRI as an Assessment Tool in Carcinoma Cervix Patients Undergoing Chemoradiation

S. Pradhan 1 , R. Ranjan 2 , A. Verma 3 , T. Singh 4 , L.M. Aggarwal 5 , R. Singh 2 , U.P. Shahi 6

1 Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Radiation Oncology, Varanasi-221005, India; 2 State Superspeciality Cancer Institute and Hospital, Radiation Oncology, Lucknow-226002, India; 3 Institute of Medical Sciences, Banaras Hindu University, Radiodiagnosis & Imaging, Varanasi-221005, India; 4 Institute of Medical Sciences, Banaras Hindu University, Division of Biostatistics, Varanasi-221005, India; 5 Institute of Medical Sciences, Banaras Hindu University, Radiotherapy and Radiation Medicine, Varanasi-221005, India; 6 Institute of Medical Sciences, Banaras Hindu University, Radiation Oncology, Varanasi-221005, India Purpose or Objective The present study was conducted to evaluate disease and response to treatment in cancer cervix patients undergoing chemoradiation, using Functional MRI and Apparent Diffusion Coefficient (ADC) mapping. Materials and Methods Present prospective study included 38 histopathologically proven patients. All patients underwent MRI before external radiotherapy (EBRT), before intracavitary application (ICR) and 3 months after treatment completion. Along with regular MRI sequences each patient underwent functional MRI, wherein DWI (Diffusion Weighted Imaging) and DCE (Dynamic Contrast Enhanced) were done. ADC maps were generated automatically with manufacturer’s software. ADC values in the tumours were documented using manual placement of regions-of-interest (ROIs) by two radiologists on pre-, mid- and post- treatment scans. The ROIs in tumours were drawn to include at least 3/4 th tumour possible in all images having visible tumour. In complete regression, ROIs were drawn over projected area of previously documented tumour bulk. On pre-ICR evaluation, patients without and with residual disease were labeled as Group-1 and Group-2, respectively.