ESTRO 2022 - Abstract Book

S856

Abstract book

ESTRO 2022

necrosis, and, overall, to the development of an aggressive phenotype and resistance to treatment. These aspects prompted the extensive study of tumour hypoxia, mostly focusing on correlations between tumour hypoxia prior the treatment and the treatment outcome. Several treatment approaches, techniques and strategies have been proposed and applied aiming at counteracting the expected (chemo)radio-resistance of the tumour cells associated with the presence of tumour hypoxia at the start of the treatment. Tumour hypoxia, however, is not a static feature but a dynamic one, changes in the oxygen availability to the cells being expected to occur during the course of the treatment. This talk will introduce the modelling framework for accounting for changes in tumour hypoxia and hence for modelling the re-oxygenation of the cells. The talk will also present the application of the modelling of tumour oxygenation and re-oxygenation for predicting the probability of controlling the tumour under various scenarios regarding the irradiation procedure involving various radiation qualities, techniques, and fractionation schedules. The theoretical advantage of employing computational models for simulating virtual tumoral systems with respect to their radiobiological environment focusing on the oxygenation and availability of nutrients, while accounting for its dynamic character, will also be presented. The examples emphasizing the role of modelling the re-oxygenation on understanding the outcome of clinical studies will focus on hypofractionated treatments. Finally, the talk will also provide an insight on modelling the changes in the oxygenation of the tumour, and hence the re- oxygenation, based on functional imaging, more specifically based on longitudinal PET imaging sessions with dedicated tracers for tumour hypoxia performed primarily for monitoring the tumour response to radiotherapy.

Symposium: Changes in disease pattern after the pandemic

SP-0995 The economic impact of avoidable cancer deaths caused by diagnostic delay during the COVID-19 pandemic

A.Aggrawal

UK Abstract not available

SP-0996 How did Italian radiotherapy centres deal with the COVID-19 pandemic?

A.R. Filippi 1

1 Fondazione IRCCS Policlinico San Matteo, Radiation Oncology, Pavia, Italy

Abstract Text Italian Radiotherapy Centers were among the first to face the COVID-19 pandemic. In particular, those located close to the epicenter of the COVID-19 spread in Lombardy. In my presentation, I will briefly outline the Italian situation for Radiation Oncology Departments at the first and second wave, focusing on the impact on patients, indications, the radiotherapy workflow, and personnel. We collected a lot of data by using the radiotherapy network of Lombardy and, in the second phase, The Italian network through our national Scientific Society. The result of this work did originate practical guidelines on patients' and personnel protection. In addition, it provided us with a handy tool for individualizing our approach to COVID-19 based on the local situations and needs.

SP-0997 The impact of the COVID-19 pandemic on radiotherapy services in England

K. Spencer

UK Abstract not available

SP-0998 Impact of COVID-19 on cancer care in India

P. Ranganathan

India Abstract not available

Symposium: Adaptation and automation: The new frontier in radiotherapy

SP-0999 Adapting and automating our professional roles: Challenges and opportunities

M. Velec 1

1 Princess Margaret Cancer Centre, Radiation Medicine Program, Toronto, Canada

Abstract Text Adaptive radiotherapy is increasingly being applied in the clinic in response to changes in patient anatomy. This will improve the precision of treatment and clinical outcomes. Traditionally limited by the availability of adaptive tools that facilitate clinical workflows, the widespread growth in automation of segmentation, planning, QA and treatment delivery is poised to make adaptation more commonplace. Supported by efficient tools, practical adaptive workflows are shifting roles and responsibilities within the multi-disciplinary team. RTTs for example have implemented models of care within standard