ESTRO 2022 - Abstract Book

S899

Abstract book

ESTRO 2022

increased side-effects during MRRTs. Despite 65% (n=13) of the patients reporting reduced fear of treatment with increasing number of RTs, 45% (n=9) patients reported an increase of psychological distress with increasing numbers of RTs. While global health status was similar to the EORTC-QLQ-C30 general cancer population (55.8 vs. 61.3, p=ns.), patients having received MRRT reported increased fatigue (51.1 vs. 34.6, p=0.006). Moreover, patients of this study reported an impaired role functioning (56.7 vs. 70.5, p=0.05) and social functioning (57.5 vs. 75.0, p=0.05, Table 1).

Figure 1: Patient-reported experiences, satisfaction and psychological distress levels

Conclusion This cross-sectional cohort study evaluated a growing patient population, which remained largely uninvestigated in the literature: long-term cancer patients treated with multiple courses of radiotherapy. We observed increased levels of fatigue and reduced social functioning, indicating this as a vulnerable population. Patient-reported experiences and satisfaction about their multiple courses of radiotherapy were positive, with respect to efficacy and tolerability of radiotherapy. Further research is required to better understand the needs of these patients and to more accurately tailer their multi-modality and multi-professional treatment.

PO-1064 A Registry for Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL)

M. Jameson 1 , V. Batumalai 1 , A. Woods 2 , T. Twentyman 1 , V. Sproule 2 , J. Christiansen 3 , N. Kennedy 3 , M. Marney 1 , K. Barooshian 4 , M. Plit 5 , J. Lynch 2 , R. Jagavkar 1 , H. Ormandy 6 , J. Christodouleas 7 , F. Pietzsch 5 , J. de Leon 1 , P. Foley 5 1 GenesisCare, Oncology, Sydney, Australia; 2 GenesisCare, Oncology, Newcastle, Australia; 3 GenesisCare, Innovations, Sydney, Australia; 4 GenesisCare, Insights, Sydney, Australia; 5 GenesisCare, CRO, Sydney, Australia; 6 GenesisCare, CRO, Melbourne, Australia; 7 Elekta AB, Medical Affairs & Clinical Research, Atlanta, USA Purpose or Objective The pairing of magnetic resonance imaging (MRI) technology with the linear accelerator is an important recent innovation. The MR-Linac allows visualisation of anatomical and functional changes during radiotherapy (RT) and adapts the treatment to achieve optimal therapy. While the MR-Linac offers the promise of high precision treatment, it is important to evaluate this novel technology to understand the clinical outcomes achieved in the short and long term. Analysis of Data to Advance Personalised Therapy with MR-Linac (ADAPT-MRL) is a multi-site, multinational, observational cohort registry designed to