ESTRO 2022 - Abstract Book

S918

Abstract book

ESTRO 2022

PO-1083 Sleep disturbances in head and neck cancer survivors one year after radiation therapy.

V. Jerviz Guia 1 , I. Castillo Pérez 1 , L. López López 2 , J. Martín Núñez 2 , M. Martín Granados 3 , M.C. Valenza 2

1 Hospital Universitario Clínico San Cecilio, Radiation Oncology, Granada, Spain; 2 Universidad de Granada, Physical Therapy, Granada, Spain; 3 Universidad de Granada, Nursing, Granada, Spain Purpose or Objective Improvements in treatment of head and neck cancer survivors have resulted in improved long-term survival rates so, there is a growing interest in long-term consequences. The aim of this study was to evaluate the sleep disturbances in head and neck cancer survivors one year after the radiation therapy. Materials and Methods In this observational study, head and neck cancer survivors and healthy controls match by age and gender were included. These patients were evaluated one year after radiotherapy treatment. Sleep quality was evaluated by the Pittsburg Sleep Quality Index (PSQI). Results Finally, 30 patients and 30 healthy controls were included in this study. The main age was 63.07 years, and the 84% were women. Results are presented in the following table:

Conclusion This study has evidenced the presence of sleep disturbances in head and neck cancer survivors one year after radiotherapy.

PO-1084 Relapse pattern in relation to FDG-PET and target volumes in HPV positive/negative oropharynx cancer

K. Håkansson 1 , A.M. Lindegaard 1 , M. Bernsdorf 1 , A. Gothelf 1 , C. Andrup Kristensen 1 , L. Specht 1 , J. Friborg 1 , I. Richter Vogelius 1

1 Rigshospitalet Copenhagen University Hospital, Department of Oncology, Copenhagen, Denmark

Purpose or Objective It is known that patients with HPV positive squamous cell carcinoma of the oropharynx (OPSCC) have a lower absolute risk of locoregional relapse (LRR) and a relatively higher rate of distant metastasis than HPV negative OPSCC patients. Therefore, it is not unlikely that the relapse pattern within different parts of the tumor/elective volumes also differs for this patient group. This could potentially influence how the distribution of radiation dose should ideally be optimized. The aim of the current work was to compare the relapse pattern in HPV negative and positive OPSCC patients, in relation to FDG-PET avid volumes and RT target structures at baseline. In addition, we wanted to see if the findings of a previous study in a mixed HNSCC population 1 – that most relapses originate within the FDG-PET avid volume – was valid also in the current population of OPSCC patients only. Materials and Methods Among 632 OPSCC patients treated 2009-2017, 40 patients with known HPV status and isolated LRR were included. Patients where journal charts indicated persistent disease after RT were excluded (independent chart review is ongoing). Oncologists contoured relapse volumes (RV) on relapse scans (CT, PET/CT or MR). The relapse scans and RV structures were deformably registered to the planning CT, and the point of origin (POI) was estimated using a nidus/centre of volume strategy 1 . The relapse (POI) positions were analyzed in relation to the following volumes/targets: FDG-PET avid volume (GTV-PET), gross tumor volume (GTV) and high-dose clinical target volume (CTV1), all 66-68 Gy. Elective volume (CTV-E), 50-60 Gy. The