ESTRO 2022 - Abstract Book

S938

Abstract book

ESTRO 2022

Conclusion Inflammatory markers like NLR and PLR in HNSCC patients receiving definitive chemoradiotherapy are independent prognostic factors. Higher NLR and PLR is associated with sarcopenia and worse treatment outcomes. These tumors tend to be more aggressive as well.

PO-1105 Prognostic analysis of different T classification in N3 nasopharyngeal carcinoma patients

S. Chiang 1 , W. Liu 1 , Y. Lin 1

1 Kaohsiung Veterans General Hospital, Radiation Oncology, Kaohsiung City, Taiwan

Purpose or Objective No consensus has been reached on the risk factor of distant metastasis and the benefit of induction chemotherapy in advanced stage nasopharyngeal carcinoma (NPC). We aimed to investigate the clinical outcome and prognostic factors of different T classification in the initially clinical N3M0 NPC patients. Materials and Methods This study included clinical N3M0 NPC patients from January, 2012 to December, 2020 in a single institute. All T- and N- classification were reviewed by pretreatment MRI according to the 8th AJCC staging system. In order to focus on the effect of the location in cervical lymphadenopathy, patients without lymph node metastasis below the caudal border of cricoid cartilage were excluded. All patients received curative radiotherapy with 69.96-74.0 Gy. Any combination of systemic treatment was allowed, including induction, concurrent and adjuvant chemotherapy. The endpoints of 2-yr DMFFS (distant metastasis failure-free survival) and 2-yr DSS (disease specific survival) were compared among different T classification. The secondary endpoint was to evaluate possible prognostic factors in these patients. Results Fifty-two patients were included in the study. The median follow-up time was 4.3 years with 10 distant metastasis events recorded. There were 13 patients in T1 classification, 11 in T2 classification, 19 in T3 classification and 9 in T4 classification. Comparing the patients in T1 classification with T2-4 classification, the patients in T1 classification have a trend of lower 2-yr DMFFS (69.2% v.s. 89.7%, p=0.073) and 2-yr DSS (76.9% v.s. 94.9%, p=0.067). The hazard ratio of 2-yr DMFFS and 2-yr DSS was 3.296 (95% CI [0.823-13.202]) and 4.578 (95% CI [0.765-27.401]), respectively. Conclusion Our preliminary results suggested a trend that the patients with T1N3 NPC have higher risk of distant metastasis and lower 2-yr survival rate. Higher intensity of induction chemotherapy may lead to a better control of distant metastasis rate and survival. Pretreatment PET/CT was also considered in these patients for detecting early metastasis. Further studies with a larger population and specific prognostic factors are needed. 1 The University of Manchester, Division of Cancer Sciences, Manchester, United Kingdom; 2 North Manchester General Hospital, Head and Neck Oncology and Voice, Manchester, United Kingdom; 3 The Christie NHS Foundation Trust, Clinical Oncology, Manchester, United Kingdom Purpose or Objective Experiencing difficulties swallowing, or dysphagia, is a common side effect of head and neck radiotherapy. It is experienced by more than 80% of the patients at the end of treatment, with a significant proportion of patients having permanent impairment of swallowing sufficient to cause aspiration. For these patients, modification of diet, with potential requirement for enteral feeding, is generally recommended with consequent negative effect on long term quality of life. There is an unmet clinical need to better predict the long-term aspiration risk during initial discussions with patients of treatment side effects. In this study, we present a simple model, including baseline variables to predict aspiration risk at 1 year, assessed via 100 ml water test. Materials and Methods Data from 108 oropharyngeal cancer patients were collected, including baseline clinical and tumour factors and various pre-treatment dysphagia scores: M.D. Anderson Dysphagia Inventory (MDADI), water test (WT), performance status scale for normalcy of diet (HN-PSS), table 1. A logistic regression predicting WT failure (defined as the patient coughing, having a wet voice quality post swallow, or not being able to finish the task) at 1 year was conducted. The final model was found by performing backward variable selection with bootstrapping (keeping top 3 selected variables, n=1000) and adjusting for internal overfitting using uniform shrinkage (based on optimism-adjusted calibration slope, n=1000). Model performance was assessed using area under the curve (AUC) of the receiver operating characteristic curve. PO-1106 HPV Status and Fitness Associated With Aspiration Risk at One Year After Head and Neck Radiotherapy E.M. Vasquez Osorio 1 , D. Ganderton 2 , A. Abravan 1 , A. Green 1 , A. McPartlin 3