ESTRO 2022 - Abstract Book

S974

Abstract book

ESTRO 2022

HFRT is a feasible and safe treatment option, for malignant gliomas of non-elderly patients. We identified good survival prognostic factors, such as KPS >90, age <50, total and partial tumor resection, and concomitant TMZ. Treatment tolerance was acceptable and comparable with international published trials.

PO-1148 Radiosurgery in brain metastases: prognostic scales

A. Ocanto 1 , R. Matute 2 , A. Castaño 2 , B. Debén 2 , M. Rodríguez 2 , I. Garrido 2 , M. Teja 2 , M. González 2 , R. Morera 2

1 University Hospital La Paz, Radiation Oncology, Madrid, Spain; 2 Universitary Hospital La Paz, Radiation Oncology, Madrid, Spain Purpose or Objective To evaluate retrospectively the utility of the Score Index for Radiosurgery (SIR) and the Graded Prognostic Assessment (GPA) in predicting survival in patients with brain metastases treated with radiosurgery (SRS). Materials and Methods 51 patients treated with radiosurgery (single fraction and multifraction) in Universitary Hospital La Paz in Madrid, Spain from 2015 to 2020 were included in the study. They were classified according to the result of the SIR and GPA, given by the variables: age, Karnofsky Performance Status (KPS), systemic disease, number of metastases and largest lesion volume. The GPA was obtained through summation of the previously noted first four prognostic factors and SIR five prognostic factors. Results The median age were 65,17 +/- 7,32 (47-78). 53% male and 47% female, 25,5% received SRS single fraction (16 and 18Gy) and 74,5% received SRS multifraction (25, 27 and 30Gy). The Kaplan–Meier method together with log rank was used to estimate and test correlation between survival and all prognostic factors. We found with GPA for each unit that the index increases, mortality is reduced by 49,9% and for each unit that the SIR increases, mortality is reduced by 22,6% (p=0,001). Conclusion SIR and GPA is a reliable prognostic score for cancer patients with brain metastases submitting to radiosurgery. This index should be tested for larger series. 1 PGIMER, CHANDIGARH, DEPARTMENT OF RADIOTHERAPY AND ONCOLOGY, CHANDIGARH, India; 2 PGIMER, DEPARTMENT OF RADIOTHERAPY AND ONCOLOGY, CHANDIGARH, India; 3 PGIMER, DEPARTMENT OF NEUROSURGERY, CHANDIGARH, India; 4 PGIMER, DEPARTMENT OF PATHOLOGY, CHANDIGARH, India Purpose or Objective Medulloblastoma is the most common malignant brain tumor of children, with a peak incidence between 5-9 years of age. Standard treatment consists of maximum safe resection followed by craniospinal irradiation (CSI) and chemotherapy. We conducted this study to analyse the impact of various clinico-pathological and treatment related parameters on outcome in medulloblastoma patients. Materials and Methods Patients records of medulloblastoma patients treated from January 2014 to December 2020 were retrieved. Survival curves were calculated using Kaplan- Meir method. Impact of various factors on outcome including age, gender, Karnofsky Performance Scale, extent of surgery, adjuvant radiotherapy and chemotherapy was analysed using log rank test and cox regression analysis. SPSS version 25.0 was used for statistical analysis. Results A total number of 115 patients were studied. Patient characteristics and treatment details have been described in Table 1 and 2 respectively. RTOG skin reactions (grade ≤ 2) were the most common acute reaction seen during RT (n=85, 83.33%). Estimated five-year OS and PFS was 69.5% and 66.8% respectively. Factors affecting OS and PFS were age, KPS, extent of resection and CSI (P < 0.05 for all). Chemotherapy significantly improved PFS (P=0.025) but not OS. Patients aged > 16 years of age has better outcome as compared to younger patients. TABLE 1 VARIABLE N (%) AGE (Median =11, range 1-52years) ≤ 16 YEARS 73 (63.47%) ≥ 17YEARS 42 (36.52%) SEX MALE 78 (67.8%) FEMALE 37 (32.2%) SYMPTOMS HEADACHE AND VOMITING 100(86.9%) PO-1149 Clinico-pathological and prognostic factors of Medulloblastoma - Tertiary care centre in India A.K. SINGLA 1 , R. MADAN 2 , N. KUMAR 2 , S. GOYAL 2 , M. TRIPATHI 3 , K. GUPTA 4 , D.K. GUPTA 2 , R. KAPOOR 2