ESTRO 2023 - Abstract Book

S175

Saturday 13 May

ESTRO 2023

of a cohort (e.g., older people without an e-mail address) the e-mail-based follow-up could be extended with a telephone- based follow-up.

PD-0239 Why is pain poorly managed in breast cancer patients? A multicenter analysis on 2104 patients C.M. Donati 1 , E. Nardi 2 , A. Zamagni 1 , G. Siepe 3 , C. Malizia 4 , F. Cellini 5 , A. Di Rito 6 , M. Portaluri 6 , C. De Tommaso 7 , A. Santacaterina 8 , C. Tamburella 8 , R. Di Franco 9 , S. Parisi 10 , S. Cossa 10 , V. Fusco 11 , A. Bianculli 11 , P. Ziccarelli 12 , L. Ziccarelli 12 , D. Genovesi 13 , L. Caravatta 13 , F. Deodato 14 , G. Macchia 14 , F. Fiorica 15 , G. Napoli 15 , M. Buwenge 16 , R. Rossi 17 , S. Cammelli 1 , M. Maltoni 18 , A.G. Morganti 1 1 Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum University of Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 2 Medical Statistics, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy; 3 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4 Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5 Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Università Cattolica del Sacro Cuore, Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy., Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy; 6 IRCCS Istituto Tumori, "Giovanni Paolo II", Bari, Italy; 7 General Hospital, "Perrino", Brindisi, Italy; 8 U.O. di Radioterapia, AOOR PAPARDO PIEMONTE, Messina, Italy; 9 S.C. di Radioterapia, dell’Istituto Nazionale Tumori Pascale, Napoli, Italy; 10 Radioterapia Opera di S. Pio da Pietralcina, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 11 IRCCS, CROB, Rionero In Vulture, Italy; 12 U.O. Radioterapia Oncologica, S.O. Mariano Santo, Cosenza, Italy; 13 Radioterapia, Università degli Studi G. D’Annunzio, Chieti, Italy; 14 Radiotherapy Unit, Gemelli Molise Hospital, Catholic University of Sacred Heart, Campobasso, Italy; 15 U.O.C.di Radioterapia e Medicina Nucleare, Ospedale Mater Salutis di Legnago, Verona, Italy; 16 Radiation Oncology, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy; 17 IRCCS, Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy; 18 Medical Oncology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy Purpose or Objective Treatment of pain is frequently inadequate in cancer patients, especially in subjects with non-neoplastic pain (versus neoplastic) and undergoing curative treatment (versus palliative). Moreover, several studies based on the Pain Management Index (PMI) showed that also breast cancer (BCa) is correlated with pain under-treatment. Aim of this analysis is to evaluate whether the poor pain management in BCa patients is due to the non-neoplastic origin of pain (from surgical scar) and to the adjuvant purpose of therapy in most subjects and/or to the female gender. Materials and Methods Data on gender, age, ECOG Performance Status, RT aim, primary tumor, tumor stage, intensity of pain measured with the Numeric Rating Scale (NRS), type of pain (cancer pain [CP], non-cancer pain [NCP], mixed pain [MP]) were collected. A Pain Score was defined with values between 0 (no pain; NRS: 0) and 3 (severe pain; NRS: 7-10). An Analgesic Score was defined with values between 0 (no pain medication) and 3 (use of strong opioids). The PMI was calculated by subtracting the pain score from the analgesic score. A negative PMI value indicates an inadequate analgesic prescription. This study was approved by the Ethical Committee of the participating centers (ARISE-1 study). Results The results of our study are shown in Table 1. The analysis confirmed the lower adequacy of pain management in BCa patients, with statistically significant differences in both subjects with CP and NCP. However, the incidence of PMI<0 was significantly higher only in BCa patients undergoing curative therapy and not in those treated with palliative radiotherapy. Finally, the incidence of PMI<0 was more than double, in patients with BCa, compared to patients with other female cancers (cervix, endometrium) with a trend towards statistical significance.

Conclusion Inadequate pain management in BCa is largely, but not only, due to the curative intent of therapy in the majority of patients and particularly to the very high rate (81.1%) of patients with PMI<0 within subjects with NCP. Instead, belonging to the female gender does not represent in itself a cause of inadequate pain management.

PD-0240 Ten-year outcomes of SBRT for oligometastatic breast cancer (OMBC): does synchronous OMBC benefit?