ESTRO 2023 - Abstract Book

S1906

Digital Posters

ESTRO 2023

Conclusion The dosimetric impact of a higher OARs dose in DA due to volumetric changes was minimal and was not predictive of detrimental clinical toxicity apart from rectal D0.03 cc ≥ 78.2Gy for Grade 2 GI toxicity. For GU toxicity, smaller prostate volumes demonstrated a minor protective effect. The developed MV models for HR-PCa treated using inverse planning techniques to predict the risk of late GI and GU toxicity at two years post-RT follow-up will be able to provide recommendations to facilitate dose escalation strategies.

PO-2119 Repeatability of Voxel-Based Analysis pipeline in radiation oncology: a first pilot experiment

S. Monti 1 , E. Mylona 2 , R. de Crevosier 2 , C. Fiorino 3 , T. Rancati 4 , O. Acosta 2 , G. Palma 5 , L. Cella 1

1 National Research Council, Institute of Biostructures and Bioimaging, Napoli, Italy; 2 University of Rennes, CLCC Eugène Marquis, INSERM, LTSI, Rennes, France; 3 San Raffaele Scientific Institute, Medical physics, Milano, Italy; 4 Fondazione IRCCS Istituto Nazionale dei Tumori, Prostate Cancer Program, Milano, Italy; 5 National Research Council, Institute of Nanotechnology, Lecce, Italy Purpose or Objective Recently the value of the Voxel Based (VB) analysis in radiation therapy oncology has been recognized (Palma et al 2019). However, the introduction of VB approaches in clinical scenarios and their inclusion in the radiation therapy (RT) planning workflow are still far. In this context, studies for VB analysis technical validation are required. In this framework, the repeatability of resulting spatial dose patterns associated with specific outcomes represents a first relevant step. The purpose of our analysis was to compare the results obtained by applying VB analyses in two different research groups on the same cohort of patients.