ESTRO 2023 - Abstract Book

S200

Saturday 13 May

ESTRO 2023

Conclusion Our data suggest a locally lymphodepletive effect of NRT on breast TIME with NRT dose-volumes and sequencing schedules used in these trials. However, the correlations between outcome and sTILs at both baseline and time of surgery in patients receiving NRT suggest a complex underlying relationship between RT and the immune response. Ongoing work on these samples including multiplex immunofluorescence and TCR-seq will elucidate this further, and ultimately inform the rational design of future RT-ICB combination trials. OC-0263 CD122-directed IL-2/ α IL-2 complexes enhance abscopal responses to radiation combined with anti-PD-1 K. Onyshchenko 1,2,3,4 , R. Luo 1,5 , A. Grosu 1,3,6 , E. Firat 1 , G. Niedermann 1,3,4 1 University of Freiburg, Department of Radiation Oncology, Faculty of Medicine, Freiburg im Breisgau, Germany; 2 University of Freiburg, Faculty of Biology, Freiburg im Breisgau, Germany; 3 German Cancer Consortium (DKTK), Partner Site Freiburg, Freiburg im Breisgau, Germany; 4 German Cancer Research Center, DKFZ, Heidelberg, Germany; 5 West China Hospital, Sichuan University,, Department of Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, Chengdu, China; 6 German Cancer Research Center, DKFZ, Heidelberg, Germany