ESTRO 2023 - Abstract Book

S694

Monday 15 May 2023

ESTRO 2023

In the external validation cohort(Fig 2a), 48 tumours were classified as ‘hypoxic’ and had a significantly worse overall survival(log-rank test, p=0.016). The signature was also prognostic in the GSE36562 cohort(Fig 2b; p=0.034). Though hypoxia was prognostic in the univariate analysis(Fig 2c; HR=2.11; p=0.018), only concurrent chemotherapy was significant in a multivariate model(HR=3.02; p=0.015). Fig2. (A)KM plot in curated; (B)and GSE36562 cohorts; (C)Selected clinical factors.

Conclusion The 31 gene hypoxia-associated signature for cervical cancer was prognostic in external validation cohorts. Further validation is required to understand the clinical utility and impact on patient stratification. PD-0825 Linking Linear Energy Transfer to the surviving fraction of FaDu cells at HollandPTC C. Groenendijk 1 , T. Heemskerk 2 , M. Rovituso 3 , W. Van Burik 3 , L. Tran 4 , A. Rosenfeld 4 , D. Lathouwers 5 , J. Brown 6 1 Delft University of Technology, Radiation Science & Technology, Delft, The Netherlands; 2 Erasmus University Medical Center, Department of Molecular Genetics, Rotterdam, The Netherlands; 3 HollandPTC, Research & Development, Delft, The Netherlands; 4 University of Wollongong, Centre for Medical Radiaton Physics (CMRP), Wollongong, Australia; 5 Delft